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KMID : 0381920080380030206
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Korean Journal of Microscopy
2008 Volume.38 No. 3 p.206 ~ p.212
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Effects of 6-aminonicotinamide on the Testes of Golden Hamster
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Lee Jin-Suk
Choi Byoung-Young
Kim Dong-Heui
Jung Won-Sug
Cho Byung-Pil
Yang Young-Chul
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Abstract
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In this study morphological changes of the testes of golden hamsters treated with 6-aminonicotinamide (6-AN, 10 mg/kg body weight) in every two days were investigated using light and transmission electron microscopes. After the 7th injection of 6-AN, body weights of hamsters were significantly reduced, and the weight of testes were markedly reduced in the group of hamsters after 5th injections. Degeneration of seminiferous epithelium appeared first in the group receiving 5th injections, which were followed by severe degenerations after the 9th injection. In the degenerated seminiferous epithelium, deep vacuolization, and destruction of spermatogenic cells and Sertoli cells were also oberved. Multinuclear giant cells were also observed in the lumen of destructed seminiferous epithelium. But there were no edematous changes in the interstitial tissue, and the Leydig cells were found to be relatively intact. Therefore, these results show that 6-AN trigger severe morphological alteration of the spermatogenic cells and Sertoli cells, however Leydig cells are unaltered by 6-AN.
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KEYWORD
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6-aminonicotinamide, Spermatogenic cell, Sertoli cell, Leydig cell
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